Karyopharm Therapeutics (KPTI) Latest Stock Analysis Report – Oct 15, 2026, 4:00 PM ET
Updated Oct 15, 2026, 4:00 PM ET
- Closed at $0.35, +11.43% vs the prior close of $0.31.
- Volume 1.33M shares, 0.9x its 50-day average.
- New SEC filings: 8-K (Oct 14, 2026).
- No new insider buys or sales reported since the prior session.
KPTI jumps 11.4% to $0.35. Closed at $0.35, +11.43% vs the prior close of $0.31. Day range $0.31–$0.35, opened at $0.31.
KPTI daily analysis — what happened
A plain-English, data-only note written after every US trading day. Newest first; older days stay archived below.
Oct 15, 2026 — KPTI jumps 11.4% to $0.35
- Closed at $0.35, +11.43% vs the prior close of $0.31. Day range $0.31–$0.35, opened at $0.31.
- Volume was 1.33M shares, 0.9x its 50-day average of 1.41M.
- Price is -77.2% vs its 50-day average ($1.54) and -94.5% vs its 200-day average ($6.43).
- 52-week range $0.31–$10.99; today's close sits at 0% of that range, 96.8% below the 52-week high.
Oct 14, 2026 — KPTI slides 26.2% to $0.31, a 52-week low, 3 down days in a row
- Closed at $0.31, -26.23% vs the prior close of $0.43. Day range $0.31–$0.43, opened at $0.43.
- Volume was 2.08M shares, 1.4x its 50-day average of 1.45M.
- Price is -79.9% vs its 50-day average ($1.57) and -95.1% vs its 200-day average ($6.46).
- 52-week range $0.31–$10.99; today's close sits at 0% of that range, 97.1% below the 52-week high.
- That makes 3 straight losses.
- SEC filings that day: 8-K.
Oct 13, 2026 — KPTI slides 15.4% to $0.43, a 52-week low
- Closed at $0.43, -15.45% vs the prior close of $0.50. Day range $0.40–$0.50, opened at $0.49.
- Volume was 1.75M shares, 1.2x its 50-day average of 1.50M.
- Price is -73.4% vs its 50-day average ($1.60) and -93.4% vs its 200-day average ($6.50).
- 52-week range $0.40–$10.99; today's close sits at 0% of that range, 96.1% below the 52-week high.
Oct 12, 2026 — KPTI slides 16.5% to $0.50, a 52-week low
- Closed at $0.50, -16.53% vs the prior close of $0.61. Day range $0.50–$0.61, opened at $0.59.
- Volume was 895.10K shares, 0.5x its 50-day average of 1.93M — lighter than usual.
- Price is -69.1% vs its 50-day average ($1.63) and -92.3% vs its 200-day average ($6.53).
- 52-week range $0.50–$10.99; today's close sits at 0% of that range, 95.4% below the 52-week high.
Oct 9, 2026 — KPTI rises 0.8% to $0.61
- Closed at $0.61, +0.83% vs the prior close of $0.60. Day range $0.56–$0.62, opened at $0.60.
- Volume was 963.00K shares, 0.5x its 50-day average of 2.00M — lighter than usual.
- Price is -63.6% vs its 50-day average ($1.66) and -90.8% vs its 200-day average ($6.57).
- 52-week range $0.56–$10.99; today's close sits at 0% of that range, 94.5% below the 52-week high.
Oct 8, 2026 — KPTI slides 7.0% to $0.60, a 52-week low, 6 down days in a row
- Closed at $0.60, -6.98% vs the prior close of $0.64. Day range $0.60–$0.64, opened at $0.63.
- Volume was 870.20K shares, 0.4x its 50-day average of 2.00M — lighter than usual.
- Price is -66.5% vs its 50-day average ($1.79) and -90.9% vs its 200-day average ($6.60).
- 52-week range $0.60–$10.99; today's close sits at 0% of that range, 94.5% below the 52-week high.
- That makes 6 straight losses.
Oct 7, 2026 — KPTI dips 0.8% to $0.64, a 52-week low, 5 down days in a row
- Closed at $0.64, -0.77% vs the prior close of $0.65. Day range $0.62–$0.69, opened at $0.65.
- Volume was 758.70K shares, 0.4x its 50-day average of 1.99M — lighter than usual.
- Price is -66.3% vs its 50-day average ($1.91) and -90.3% vs its 200-day average ($6.63).
- 52-week range $0.62–$10.99; today's close sits at 0% of that range, 94.1% below the 52-week high.
- That makes 5 straight losses.
Oct 6, 2026 — KPTI slides 3.1% to $0.65, a 52-week low, 4 down days in a row
- Closed at $0.65, -3.13% vs the prior close of $0.67. Day range $0.63–$0.71, opened at $0.69.
- Volume was 1.18M shares, 0.6x its 50-day average of 1.98M — lighter than usual.
- Price is -68.2% vs its 50-day average ($2.04) and -90.2% vs its 200-day average ($6.66).
- 52-week range $0.63–$10.99; today's close sits at 0% of that range, 94.1% below the 52-week high.
- That makes 4 straight losses.
Oct 5, 2026 — KPTI slides 16.3% to $0.67, a 52-week low, 3 down days in a row
- Closed at $0.67, -16.33% vs the prior close of $0.80. Day range $0.63–$0.80, opened at $0.80.
- Volume was 1.98M shares, 1.0x its 50-day average of 1.96M.
- Price is -69.1% vs its 50-day average ($2.17) and -90.0% vs its 200-day average ($6.69).
- 52-week range $0.63–$10.99; today's close sits at 0% of that range, 93.9% below the 52-week high.
- That makes 3 straight losses.
Oct 2, 2026 — KPTI slides 7.5% to $0.80, a 52-week low
- Closed at $0.80, -7.50% vs the prior close of $0.87. Day range $0.75–$0.89, opened at $0.86.
- Volume was 2.34M shares, 1.2x its 50-day average of 1.92M.
- Price is -65.2% vs its 50-day average ($2.31) and -88.1% vs its 200-day average ($6.72).
- 52-week range $0.75–$10.99; today's close sits at 1% of that range, 92.7% below the 52-week high.
KPTI latest news & SEC filings
Every SEC filing by or about KPTI in the last 120 days, explained in plain English. Updated daily, with a same-day refresh for new filings.
Oct 14, 2026 · Form 8-K — Major event / current report
Current report — a filing companies must make within 4 business days of a major event
- Item 8.01 — Reported other events the company considers important.
Oct 8, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Oct 2, 2026 · Form 4 — Insider trade
Insider trade report (Form 4) — a director, officer or 10%+ owner changed their holdings
- Abate Kristin sold 378 shares at $1.19 (≈$450) on Oct 1, 2026; now holds 23,404
Open-market purchases (P) and sales (S) are shown in colour; awards, exercises and tax withholding are routine pay-related moves. Many sales are pre-planned under 10b5-1 plans.
Sep 25, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Sep 25, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Sep 18, 2026 · Form 8-K — Major event / current report
Current report — a filing companies must make within 4 business days of a major event
- Item 3.03 — Change to shareholder rights.
- Item 5.03 — Amended its charter or bylaws / changed fiscal year.
Sep 11, 2026 · Form 8-K — Major event / current report
Current report — a filing companies must make within 4 business days of a major event
- Item 1.01 — Signed a material agreement.
- Item 2.04 — Event that accelerates a debt obligation.
- Item 3.02 — Sold unregistered shares.
- Item 8.01 — Reported other events the company considers important.
Sep 4, 2026 · Form SCHEDULE 13G — Passive stake (13G)
Passive stake (13G) — an investor reported owning more than 5%
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Sep 2, 2026 · Form 4 — Insider trade
Insider trade report (Form 4) — a director, officer or 10%+ owner changed their holdings
- Abate Kristin sold 19 shares at $2.02 (≈$38) on Sep 1, 2026
Open-market purchases (P) and sales (S) are shown in colour; awards, exercises and tax withholding are routine pay-related moves. Many sales are pre-planned under 10b5-1 plans.
Aug 31, 2026 · Form 8-K — Major event / current report
Current report — a filing companies must make within 4 business days of a major event
- Item 8.01 — Reported other events the company considers important.
Aug 14, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Aug 14, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Aug 13, 2026 · Form 10-Q — Quarterly report
Quarterly report (unaudited financial statements for the quarter)
Quarter ended Jun 30, 2026:
- Revenue: $33.43M (prior year $37.93M) (-11.9% vs Jun 30, 2025)
- Net income: -$67.02M (prior year -$37.25M) (loss widened vs Jun 30, 2025)
- Diluted EPS: -$2.32 (prior year -$4.32) (loss narrowed vs Jun 30, 2025)
Aug 13, 2026 · Form 8-K — Major event / current report
Current report — a filing companies must make within 4 business days of a major event
- Item 2.02 — Reported results of operations (earnings release).
This is a results-day filing: the earnings press release is attached as an exhibit.
Aug 12, 2026 · Form SCHEDULE 13G/A — Update to a passive 5%+ stake (13G)
Update to a passive 5%+ stake (13G)
Filed by an outside investor (not the company). It reports a holding of more than 5% of a share class; percentage and holder name are in the filing.
Things to know before you trade KPTI
- Last results release: Aug 13, 2026 (8-K Item 2.02). Previous ones: May 14, 2026, Feb 12, 2026, Jan 12, 2026. Based on that rhythm, the next report is likely around Nov 12, 2026 — an estimate, not a confirmed date.
- How much it moves: over the last 20 sessions the average daily move was 9.03% (largest 28.9%). That is a volatile stock.
- Liquidity: about 1.42M shares (≈$497.61K) trade per day on average. Thin volume can mean wider bid/ask spreads.
- 52-week position: $0.35 vs a range of $0.31–$10.99 (0% of the range).
- Dividends: no cash dividends in the last 2 years.
- Splits: 1:15 on Feb 26, 2025
- Insider trades (Form 4, last 12 months, recent 25 shown): 0 open-market buys, 20 sales; latest: Kristin Abate sold 19 shares on Sep 1, 2026.
- Latest filings: 8-K Oct 14, 2026; 8-K Sep 18, 2026; 8-K Sep 11, 2026.
- Share count: 22.68M shares outstanding (Aug 6, 2026), +161.6% vs a year earlier — notable dilution.
- Listing: Nasdaq · industry: Pharmaceutical Preparations.
KPTI market data (last 20 sessions)
| Date | Open | High | Low | Close | Volume |
|---|---|---|---|---|---|
| Oct 15, 2026 | 0.31 | 0.35 | 0.31 | 0.35 | 1.33M |
| Oct 14, 2026 | 0.43 | 0.43 | 0.31 | 0.31 | 2.08M |
| Oct 13, 2026 | 0.49 | 0.50 | 0.40 | 0.43 | 1.75M |
| Oct 12, 2026 | 0.59 | 0.61 | 0.50 | 0.50 | 895.10K |
| Oct 9, 2026 | 0.60 | 0.62 | 0.56 | 0.61 | 963.00K |
| Oct 8, 2026 | 0.63 | 0.64 | 0.60 | 0.60 | 870.20K |
| Oct 7, 2026 | 0.65 | 0.69 | 0.62 | 0.64 | 758.70K |
| Oct 6, 2026 | 0.69 | 0.71 | 0.63 | 0.65 | 1.18M |
| Oct 5, 2026 | 0.80 | 0.80 | 0.63 | 0.67 | 1.98M |
| Oct 2, 2026 | 0.86 | 0.89 | 0.75 | 0.80 | 2.34M |
| Oct 1, 2026 | 1.19 | 1.20 | 0.85 | 0.87 | 2.66M |
| Sep 30, 2026 | 1.26 | 1.27 | 1.18 | 1.22 | 1.75M |
| Sep 29, 2026 | 1.62 | 1.62 | 1.20 | 1.21 | 1.86M |
| Sep 28, 2026 | 1.59 | 1.66 | 1.54 | 1.62 | 326.50K |
| Sep 25, 2026 | 1.73 | 1.77 | 1.57 | 1.62 | 1.47M |
| Sep 24, 2026 | 1.73 | 1.77 | 1.71 | 1.73 | 677.30K |
| Sep 23, 2026 | 1.81 | 1.84 | 1.66 | 1.75 | 957.50K |
| Sep 22, 2026 | 1.87 | 1.92 | 1.78 | 1.82 | 986.80K |
| Sep 21, 2026 | 1.85 | 1.93 | 1.78 | 1.86 | 1.62M |
| Sep 18, 2026 | 1.77 | 1.88 | 1.67 | 1.88 | 1.90M |
About Karyopharm Therapeutics
Karyopharm Therapeutics (KPTI) is listed on the Nasdaq and classified by the SEC under “Pharmaceutical Preparations”. Its business address is in NEWTON, MA. State of incorporation: DE. Fiscal year ends December 31. SEC CIK 1503802.
KPTI board of directors & executives
From SEC Form 3/4/5 insider filings made in the last 12 months (date = latest filing).
Directors
| Name | Role | Latest filing |
|---|---|---|
| Garen G Bohlin | Director | May 26, 2026 |
| Barry E Greene | Director | May 26, 2026 |
| Christy J. Oliger | Director | May 26, 2026 |
| Deepika Pakianathan | Director | May 26, 2026 |
| Richard A. Paulson | President and CEO | May 15, 2026 |
| Chen Schor | Director | May 26, 2026 |
| Zhen Su | Director | May 26, 2026 |
Executive officers
| Name | Title | Latest filing |
|---|---|---|
| Kristin Abate | Chief Accounting Officer | Sep 2, 2026 |
| Sohanya Roshan Cheng | EVP & Chief Commercial Officer | May 15, 2026 |
| Lori Macomber | EVP, CFO & Treasurer | Feb 4, 2026 |
| Michael Mano | EVP, CLO&Secretary | May 15, 2026 |
| Richard A. Paulson | President and CEO | May 15, 2026 |
| Stuart Poulton | EVP, Chief Development Officer | Jul 30, 2026 |
| Reshma Rangwala | EVP & Chief Medical Officer | May 15, 2026 |
Recent insider buys & sales
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Sep 1, 2026 | Kristin Abate | Sale | 19 | $2.02 |
| Jul 28, 2026 | Stuart Poulton | Sale | 189 | $7.10 |
| May 14, 2026 | Sohanya Roshan Cheng | Sale | 324 | $9.50 |
| May 14, 2026 | Reshma Rangwala | Sale | 408 | $9.50 |
| May 14, 2026 | Richard A. Paulson | Sale | 2,203 | $9.50 |
| May 14, 2026 | Michael Mano | Sale | 266 | $9.50 |
| May 14, 2026 | Kristin Abate | Sale | 53 | $9.50 |
| May 14, 2026 | Stuart Poulton | Sale | 403 | $9.50 |
| Apr 21, 2026 | Reshma Rangwala | Sale | 449 | $8.94 |
| Mar 2, 2026 | Reshma Rangwala | Sale | 5,066 | $9.41 |
| Mar 2, 2026 | Sohanya Roshan Cheng | Sale | 4,604 | $9.41 |
| Mar 2, 2026 | Richard A. Paulson | Sale | 12,361 | $9.41 |
| Mar 2, 2026 | Michael Mano | Sale | 3,526 | $9.41 |
| Mar 2, 2026 | Kristin Abate | Sale | 559 | $9.41 |
| Mar 2, 2026 | Stuart Poulton | Sale | 5,101 | $9.41 |
KPTI financials (annual, from XBRL filings)
| Fiscal year end | Revenue | Net income | Diluted EPS | Operating cash flow |
|---|---|---|---|---|
| Dec 31, 2025 | $146.07M | $-196.04M | -17.93 | $-75.37M |
| Dec 31, 2024 | $145.24M | $-76.42M | -14.00 | $-127.49M |
| Dec 31, 2023 | $146.03M | $-143.10M | -18.79 | $-92.72M |
| Dec 31, 2022 | $157.07M | $-165.29M | -2.02 | $-149.55M |
| Dec 31, 2021 | $209.82M | $-124.09M | -1.65 | $-107.12M |
Latest balance sheet: total assets $111.32M, total liabilities $441.49M, cash $54.98M (as of Jun 30, 2026).
KPTI earnings / results-day log
| Date | Filing | Close that day |
|---|---|---|
| Aug 13, 2026 | 8-K Item 2.02 (results) | $1.99 |
| May 14, 2026 | 8-K Item 2.02 (results) | $8.90 |
| Feb 12, 2026 | 8-K Item 2.02 (results) | $8.94 |
| Jan 12, 2026 | 8-K Item 2.02 (results) | $8.19 |
| Nov 3, 2025 | 8-K Item 2.02 (results) | $6.07 |
| Oct 8, 2025 | 8-K Item 2.02 (results) | $5.90 |
| Aug 11, 2025 | 8-K Item 2.02 (results) | $3.77 |
| May 12, 2025 | 8-K Item 2.02 (results) | $6.15 |
| Feb 19, 2025 | 8-K Item 2.02 (results) | $9.00 |
| Jan 13, 2025 | 8-K Item 2.02 (results) | $10.10 |
| Nov 5, 2024 | 8-K Item 2.02 (results) | $12.69 |
| Aug 6, 2024 | 8-K Item 2.02 (results) | — |
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Information only, not investment advice. BuyMeWhiskey is not a registered investment adviser or broker-dealer; nothing here is a recommendation to buy, sell or hold any security, and there are no price targets. Data comes from SEC EDGAR filings and public end-of-day market data and may be delayed or contain errors. Verify with the company's filings before making decisions. Prices: end-of-day data as of Oct 15, 2026, 4:00 PM ET. Filings: SEC EDGAR. Updated after every US trading day.